Monday, August 24, 2020

Republiacns! Unfavorable Acts Caused The Rise Of The Kkk :: essays research papers

Republiacns! Troublesome Acts Caused The Rise of The KKK      The years after the common war were disappointing occasions for the Americans. New laws and rules were presented for which on comply with and because of the result of the common war, the individuals from the south had now to acknowledge the new subjugation laws given by the ideological groups and congress. This made strife among both northerners, who for the most part were against subjugation, and southerners. This was too valid for both ideological groups that comprised of the Republicans and the Democratics. Again the issue was consistently on the privileges of blacks. The fights with specific people who felt it their obligation to go to bat for their concept of what the American way was.      In 1866, only a year after the common war, six confederate veterans shaped a social club in the modest community of Pulaski Tennessee. These men were set out to propagate racial oppression all through the south. The social club became official. The individuals thought of the name of Ku Klux Klan. It was a name taken from the Greek word "Kuklos" which means circle. They thought of ceremonies duplicated from school cliques. They additionally appointed situations to extraordinary individuals. They were made out of the Grand Cyclop, The President, the Terrific Magi, the VP, and the Grand Exchequer, the treasurer. The Klansmen receive a uniform. The garbs were white, long robes, White veils, What's more, high pointed caps. ( Ingalls, Hoods 3 )      Adopted during 1866-67, the Republican party's Reconstruction program taken steps to flip around southern culture. The guarantee of equivalent rights for blacks went against the broadly held assessment of the white Southerners that the dark race was intrinsically sub-par. This profound situated supremacist conviction had served to legitimize bondage, and it stayed a significant hindrance to elevating blacks after the common war. For sure, Antiblack disdain drove a few whites to outrageous measures to oppose Reconstruction. ( Ingalls, Hoods 6 )      The Republicans expected that barrings the blacks from legislative issues would make the Democratics Party prevailing again in the south and in congress. Congress separated the south into five military regions constrained by military law. It removed the vote from huge quantities of radical whites. It proclaimed that all dark men could cast a ballot and hold office. What's more, it requested the dissident states to compose new and majority rule constitutions. Since Tennessee had gotten the main southern state to give dark men and liberated slaves the option to cast a ballot, it turned out to be most influenced. ( Meltzer, 23 )      With the republican party controlling state government, exconfederates started to wage war to contradict Reconstruction.

Saturday, August 22, 2020

OSHA Workplace Safety and Security Assignment Example | Topics and Well Written Essays - 2250 words

OSHA Workplace Safety and Security - Assignment Example 3. The NFPA 704 precious stone helps workers, just as firemen, recognize what risks are in structures. Name the four regions of the precious stone, including the related hues. For an additional two focuses, clarify the numbers that you may discover in the jewel; which demonstrates generally perilous and least risky. The four regions of the jewel are red (combustibility), blue (wellbeing), yellow (unsteadiness), and white (extraordinary zone with water or oxidization). Numbers inside the jewel run from zero (demonstrating insignificant danger) to four (showing extreme peril). 4. For what reason was the NFPA established in 1896? The NFPA’s crucial to lessen the overall weight of fire and different dangers on peoples’ personal satisfaction by â€Å"providing and upholding accord codes and gauges, research, instruction, and training.† 5. If it's not too much trouble coordinate the accompanying terms from part 8 with the accompanying definitions. Each answer is just u tilized once. (Insight - Get the subparts off the beaten path initial) A. NFPA 101 X B. Combustible fluid X C. Breaking point X D. Crisis activity plan X E. Combustible fluid rooms X.â

Saturday, July 25, 2020

How Sensory Adaptation Works

How Sensory Adaptation Works Theories Psychosocial Psychology Print How Sensory Adaptation Works By Kendra Cherry facebook twitter Kendra Cherry, MS, is an author, educational consultant, and speaker focused on helping students learn about psychology. Learn about our editorial policy Kendra Cherry Reviewed by Reviewed by Amy Morin, LCSW on November 27, 2019 facebook twitter instagram Amy Morin, LCSW, is a psychotherapist, author of the bestselling book 13 Things Mentally Strong People Dont Do, and a highly sought-after speaker. Learn about our Wellness Board Amy Morin, LCSW Updated on January 18, 2020 Marc Romanelli / Getty Images More in Theories Psychosocial Psychology Behavioral Psychology Cognitive Psychology Developmental Psychology Personality Psychology Social Psychology Biological Psychology Imagine that you just walked into your favorite Italian restaurant. When you first walk through the door, the delicious smell of garlic and tomatoes is almost overwhelming. You sit down to wait for a table, and after a few minutes, the scents begin to dissipate until you barely notice them. This is an example of what is known as sensory adaptation. Why We Experience Sensory Adaptation Sensory adaptation refers to a reduction in sensitivity to a stimulus after constant exposure to it. While sensory adaptation reduces our awareness of a constant stimulus, it helps free up our attention and resources to attend to other stimuli in the environment around us. All five of our senses are constantly adjusting to whats around us, as well as to us individually and what we are experiencing, such as aging or disease. Just imagine what it would be like if you didnt experience sensory adaptation. You might find yourself overwhelmed by the pungent smell of onions coming from the kitchen or the blare of the television from the living room. Since constant exposure to a sensory stimulus reduces our sensitivity to it, we are able to shift our attention to other things in our environment rather than focusing on one overwhelming stimulus. Examples of Sensory Adaptation Here are some more examples of sensory adaptation: Think about walking into a house where fried fish, sauerkraut, and head cheese were prepared for dinner. (Some dinner!) You would probably pass out at the door, yet people who had been in the house for some time wouldnt be aware of the food odors. Similarly, smokers often dont get how much nonsmokers are bothered by the smell of tobacco smoke. Why? Because sensory receptors respond less to unchanging stimuli, a process called sensory adaptation. ??When you go into a dark room or outside at night, your eyes eventually adjust to the darkness because your pupils enlarge to let in more light. Likewise, when you are in bright light, your eyes adjust by the narrowing of your pupils. This is another form of sensory adaptation.When you jump into a cold swimming pool or first get into a hot tub, the water may feel unpleasantly cold or much too hot, but eventually, your body adjusts to the temperature and it feels only mildly cool or perfectly pleasant and even, eventually, too cold.Even our h and-eye coordination adjusts when necessary. For instance, if you put on goggles that make everything appear to be a little off and you try to throw a ball at an object, eventually your sensory adaptation will take over and youll adjust enough to be able to hit it. A Word From Verywell If youve heard the term nose blind, youve heard of sensory adaption; its the same thing. (But its different from anosmia, or the inability to smell.) You also might notice that when youre away from a smell or a sound for a while, such as when you go on vacation and then return to your home, you notice it again. It will probably not take much time for you to adapt to the sensory inputs of your environment and go blind to them once again.

Friday, May 22, 2020

David Copperfield s The Upbringing Of Children - 1397 Words

David Copperfield was a novel written by Charles Dickens. Like most of Dickens other works, it was written to help teach lessons in the upbringing of children. David Copperfield came out in bits and pieces throughout the year from 1849 to 1850. The books were intended for the average family. A family would get each installment of the book as it came out, and read it together, often out loud. In order to help teach these lessons, Dickens filled David Copperfield with multiple experiences that he thought were important to help teach the characteristics that he found helped him be successful in his own life. This book became the outline of what a Dickensian book would be written like by following the life of a young boy who would have to overcome multiple setbacks in order to reach his goal. Charles Dickens was a Victorian author whose writing were often based on events from his own life. He was born on February 7, 1812 in Portsmouth, United Kingdom. His parents were John and Elizabeth Dickens. Dickens was sent to school at the age of nine to attend Wellington House Academy. However, Dickens did not stay in school for long. His father was sent to Marshalsea Prison for failing to pay a debit, so Dickens left school and tried to pay his father’s debit as best he could. Once Charles’ father settled his debit, Charles went back to Wellington House Academy. He then left Wellington House for good at the age of fourteen and became a law clerk. That also is when he became interestedShow MoreRelatedEveryone Appreciates A Good, Rags, And Oliver Twist1728 Words   |  7 Pagesalso knew people, and how poverty can effect and change them. Over the course of his life he wrote some of the most famous and beloved stories, from â€Å"A Christmas Carol,† â€Å"Grea t Expectation†, and â€Å"Oliver Twist†, to â€Å"Nicholas Nickleby† and â€Å"Davis Copperfield.† Today Dickens is considered to be by many, one of the most well-known English novelist of the Victorian era. Most people today could say that they have at least heard of one of his works in some way or another, or at the very least have witnessedRead MoreANALIZ TEXT INTERPRETATION AND ANALYSIS28843 Words   |  116 Pagesbehaviour in some significant way. Dynamic characters include the protagonists in most novels, which by virtue of their very size and scope provide excellent vehicles for illustrating the process of change. So-called initiation novels, such as David Copperfield, Huckleberry Finn and the Great Gatsby, are examples. In each case the author has arranged the events of the plot so that they reveal the slow and painful maturing of the young protagonist coming into contact with the world of adult experience

Thursday, May 7, 2020

Post Traumatic Stress Disorder ( Ptsd ) - 1589 Words

Men and Women who served for their country should be given all respect and care when they return home. Veterans come home with injuries that can affect them from living a healthy comfortable life. Their injuries can be from physical to mental injuries like PTSD (post-traumatic stress disorder) from combat. Veterans who come home with these injuries should be provided, by the government, health care where they can live an enjoyable life. Having veterans take an alternative rout like qualifying for medicade could help a lot of these people struggling. Many of these veterans are also homeless and need help finding jobs. Government programs could be put in place that could help find jobs for the veterans. Veterans should be able to come home and life a healthy happy life where they can contribute back to there societies. Governments should provide for the needs of the veterans to keep them healthy and supply them with jobs so they have food, clothes, and shelter. Veterans who come back from serving overseas are coming home with injuries that they cannot afford to get treated. Even today there are a large number of veterans that have been out of the service for many decades that can t afford their own health care or even provide new clothes and shelter for themselves. According to a research done by gathering information from Current Populations Surveys and the National Health Interview Survey from 1988 to 2005 they found that Nearly 1.8 million veterans were uninsured and notShow MoreRelatedPost Traumatic Stress Disorder ( Ptsd )990 Words   |  4 PagesPost-Traumatic Stress Disorder Post-traumatic stress disorder is a common anxiety disorder characterized by chronic physical arousal, recurrent unwanted thoughts and images of the traumatic event, and avoidance of things that can call the traumatic event into mind (Schacter, Gilbert, Wegner, Nock, 2014). About 7 percent of Americans suffer from PTSD. Family members of victims can also develop PTSD and it can occur in people of any age. The diagnosis for PTSD requires one or more symptoms to beRead MorePost Traumatic Stress Disorder ( Ptsd )1471 Words   |  6 PagesRunning head: POST-TRAUMATIC STRESS DISORDER 1 Post-Traumatic Stress Disorder Student’s Name Course Title School Name April 12, 2017 Post-Traumatic Stress Disorder Post-traumatic stress disorder is a mental disorder that many people are facing every day, and it appears to become more prevalent. This disorder is mainly caused by going through or experiencing a traumatic event, and its risk of may be increased by issuesRead MorePost Traumatic Stress Disorder ( Ptsd ) Essay1401 Words   |  6 PagesAccording to the Mayo-Clinic Post Traumatic Stress Disorder, commonly known as PTSD is defined as â€Å"Post-traumatic stress disorder (PTSD) is a mental health condition that s triggered by a terrifying event — either experiencing it or witnessing it. Symptoms may include flashbacks, nightmares and severe anxiety, as well as uncontrollable thoughts about the event† (Mayo Clinic Staff, 2014). Post Traumatic Stress disorder can prevent one from living a normal, healthy life. In 2014, Chris Kyle playedRead MorePost Traumatic Stress Disorder ( Ptsd )1198 Words   |  5 Pages Post-traumatic stress disorder(PTSD) is a mental illness that is triggered by witnessing or experiencing a traumatic event. â€Å"PTSD was first brought to public attention in relation to war veterans, but it can result from a variety of traumatic incidents, such as mugging, rape, torture, being kidnapped or held captive, child abuse, car accidents, train wrecks, plane crashes, bombings, or natural disasters such as floods or earthquakes(NIMH,2015).† PTSD is recognized as a psychobiological mentalRead MorePost Traumatic Stress Disorder ( Ptsd )1423 Words   |  6 Pages Mental diseases and disorders have been around since humans have been inhabiting earth. The field of science tasked with diagnosing and treating these disorders is something that is always evolving. One of the most prevalent disorders in our society but has only recently been acknowledged is Post Traumatic Stress Disorder (PTSD). Proper and professional diagnosis and definitions of PTSD was first introduced by the American Psychiatric Association(APA) in the third edition of the Diagnostic andRead MorePost Traumatic Stress Disorder ( Ptsd ) Essay1550 Words   |  7 PagesPost Traumatic Stress Disorder â€Å"PTSD is a disorder that develops in certain people who have experienced a shocking, traumatic, or dangerous event† (National Institute of Mental Health). Post Traumatic Stress Disorder (PTSD) has always existed, PTSD was once considered a psychological condition of combat veterans who were â€Å"shocked† by and unable to face their experiences on the battlefield. Much of the general public and many mental health professionals doubted whether PTSD was a true disorder (NIMH)Read MorePost Traumatic Stress Disorder ( Ptsd ) Essay1453 Words   |  6 Pages84.8% of those diagnosed Post-Traumatic Stress Disorder still show moderate impairment of symptoms, even 30 plus years after the war (Glover 2014). As of today, the Unites States has 2.8 million veterans who served in the Afghanistan and Iraq wars, of those it is estimated that 11 to 20% currently suffer from Post-Traumatic Stress Disorder. As of 2013, a total of 12,632 veterans of the Afghanistan and Iraq wars are currently diagnosed with Post-Traumatic Stress Disorder (Glover 2014). Of course itRead MorePost Traumatic Stress Disorder ( Ptsd ) Essay1162 Words   |  5 PagesSocial Identity, Groups, and PTSD In 1980, Post Traumatic Stress Disorder (PTSD,) was officially categorized as a mental disorder even though after three decades it is still seen as controversial. The controversy is mainly founded around the relationship between post-traumatic stress (PTS) and politics. The author believes that a group level analysis will assist in understanding the contradictory positions in the debate of whether or not PTSD is a true disorder. The literature regarding this topicRead MorePost Traumatic Stress Disorder ( Ptsd )944 Words   |  4 Pageswith Post-traumatic stress disorder (PTSD Stats). Post-Traumatic Stress Disorder is a mental disorder common found in veterans who came back from war. We can express our appreciation to our veterans by creating more support programs, help them go back to what they enjoy the most, and let them know we view them as a human not a disgrace. According to the National Care of PTSD, a government created program, published an article and provides the basic definition and common symptoms of PTSD. Post-traumaticRead MorePost Traumatic Stress Disorder ( Ptsd )1241 Words   |  5 Pages Stanley Health April 14, 2014 Post Traumatic Stress Disorder Post traumatic stressed disorder is a mental illness caused by an enormous amount of anxiety felt after a traumatic or life-threatening accident or event. This event causes intense feelings of fear and helplessness. Studies have shown that about 5 to 6 million people suffer from PTSD. (Thomas ) About 30% of those people are war veterans. Most war veterans who have served for our country who have PTSD from the war are homeless. About

Wednesday, May 6, 2020

Legos Free Essays

Legos are fantastic toys to satisfy anyone from young to old, with these toys you can build Marvel sets to Harry Potter sets. Legos have been around since 1932 and were made out of wood and metal, it is now 2018 and the legos have since then had a major progression in how they look. Nowadays legos are small plastic pieces that come in sets but back in 1932 you would just get random lego pieces and you would have to purchase more to get the right pieces for that specific set. We will write a custom essay sample on Legos or any similar topic only for you Order Now Ole Kirk Kristiansen is the founder of Lego, Ole Kirk was born in Omvrà ¥ Mark, Blà ¥hà ¸j-Filskov parish, Denmark, on April 7, 1891. When Ole got to the age of seven, he worked as a smallholder but later he moved to a farm near Filskov. On November 1903 Ole Kirk became an apprenticed as a carpenter and joiner to his brother, Kristian Bonde Kristiansen. On February 1, 1916, Ole at the age of twenty four bought Billund Maskinsnedkeri for DKK 10,000. The Billund is a community consisting of small farmers. Billund factory crafts doors, windows, kitchen cabinets, cupboards, and coffins. The USA and UK place restrictions on imports, and this brings the crisis directly to the Danish farming community in 1930. Butter and pigmeat prices fall sharply, and as these products represent a huge section of Danish exports, life becomes very difficult for Danish farmers. Many farmers are forced from their farms. The economic crisis also has serious consequences for Ole Kirk Kristiansen. Farmers and smallholders, his most important customers, can no longer afford to carry out carpentry and joinery work, and in 1931 he has no option but to let his last journeyman go. After years of being successful finally the economy hit and this made Ole switch to making toys for little kids, which became a worldwide success. 1932 is a difficult year for Ole Kirk Kristiansen. Reflecting the crisis in agriculture, his carpentry and joinery business is not doing well. He is forced to lay off his last journeyman employee, and in the midst of his economic troubles he loses his wife, and finds himself alone with four sons aged between 6 and 15 years. Ole’s son Godtfred Kirk Kristiansen would become a junior vice president of the company in 1950, on his 30th birthday. In 1957 Godtfred became a Managing Director, but the following year Godtfred became the head of the company after his father died to a heart attack on March 11, 1958. By 1960, Godtfred had bought out his three brothers to become sole proprietor of the company. Godtfred got married to a woman named Edith Kirk Christiansen which he had three kids with named Gunhild Kirk Johansen, Kjeld Kirk Kristiansen and Hanne Kristiansen. On October 1969 Hanne and Kjeld were driving home from watching a movie and the car lost control and slid off the road killing Hanne and seriously injuring Kjeld. After this incident Godtfred went into a depression and considered selling the lego company. In 1979 Godtfred son Kjeld became president and CEO of the lego company. In 2004 Kjeld stepped down from his position of president and CEO to focus on being the owner of the lego group and vice-chairman of the board. While Kjeld was maintaining his role as vice-chairman of the board KIRKBI A/S, Lego Holding A/S and the Lego Foundation. Lego is privately held and is controlled by the Kristiansen family and their foundations. Kjeld and his wife, Camilla, live in Denmark and have three children and two grandchildren. His youngest daughter is the danish dressage rider Agnete Kirk Thinggaard. The production of lego is a complex algorithm, these robots make small toys for kids and adults to play with and get lost in time building and using them. Making legos all start with tiny plastic grains called granules which come in a bunch of different colors. From there trucks filled with granules drive up to one of the lego factories all around the world, where giant hoses suck up the granules and then dump them into three story high metal silos. There are 14 silos and each one can hold up to 33 tons of granules. From the silos, the plastic granules are fed down pipes to the molding machines. Inside the molding machines, the granules are superheated to a temperature of about 450 degrees Fahrenheit. This melted plastic goo is fed into molds, little metal containers shaped like hollow lego bricks. Think of them as very complicated versions of the ice cube trays you keep in your own freezer. The molding machine applies hundreds of tons of pressure to make sure the bricks are shaped with perfect accuracy. Then they are cooled and ejected, which only takes about 10 seconds. Because of the dangerous conditions and high precision required, the molding process is almost completely automated. Finished pieces roll down conveyor belts into boxes. When a box is full, the molding machine sends a radio signal to one of the robot trucks that patrol the hall. The robot trucks are guided by grooves in the factory floor. They pick up full boxes and place them onto another conveyor belt that takes them onto the next step of the manufacturing process. The next stop in the manufacturing process is the assembly halls where details are printed on and multi-part pieces are put together. Faces, control panels, numbers, words and other decorative details are stamped onto bricks by a giant printer. Some lego pieces like minifigure legs are made up of several pieces that fit together. These complex pieces are snapped together by machines that apply pressure with great precision. The final step is putting all the right pieces together to make complete lego sets. Sets can have hundreds of different pieces, so the packaging process has to be fast and accurate. Boxes called cassettes roll on conveyor belts underneath the bins that hold each type of piece. The bins open and close to release the right number of pieces into each cassette. Finally, packing operators fold the boxes and add the building instructions and additional pieces and look out for any machine-made mistakes. How to cite Legos, Papers

Monday, April 27, 2020

What type of music is most appealing free essay sample

In 1995, the British band Oasis came out with their second and by far most popular album, (Whats the Story) Morning Glory?. This was one of the major building blocks in the musical wonderland of alternative rock. Alternative rock is a midge podgy category of music that has the rhythm and accentuated backseat of classic rock and roll but is more defined by its unconformity. This genre of music appeals to me because of its unconventional style and variety and significantly reduced desire to conform.One of the major facets of alternative rock that makes it so appealing is the unique style and variety. It is not unusual for one artist to produce many hit albums each with a slightly different sound. Beginning in 1983 and still touring today, the Red Hot Chili peppers are a prime example Of this diversity within alternative rock. Their first album, The Red Hot Chili Peppers, had a complex melodies with a strong baseline and simpler song structure. We will write a custom essay sample on What type of music is most appealing or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page These songs, including Get up and Jump, had a strong funk influences while still falling under the category of alternative rock.Compare this to their 9th studio album Stadium Arcadian, released in 2006. Keeping in character of the bands originality and out of the box style, this album was the most mellow of them all and had prominent psychedelic influences from the late ass. Due to so much unconformity many alternative rock bands dont have the large fan base that the Red Hot Chili Peppers have and are not as widely know. Its very common for many of these bands to have one hit wonders. Alternative rock is so appealing because the intent of the music isnt to be popular; it is a true expression of the artist or band as a collective group.Panic! At the Disco is a more recent band of the sass. Formed in 2004, they are mainly remembered for their two singles I Write Sins Not Tragedies and Nine in the Afternoon; both of which subsequently preceded their first two albums. Alternative rock really separates the boys from the men in the sense of commitment to their love of music;

Thursday, March 19, 2020

Intercultural Sensitivity.

Intercultural Sensitivity. The developmental stage of intercultural sensitivity that best fits me at this point in my life is the one listed as number five, Adaptation. I feel this way because I can evaluate other's behavior from their frame of reference in most instances, and can adapt my behavior to fit the norms of their culture, if needed. I am a very flexible person when it comes to cultural values. I know what I value, but I also know that the things I value are not always the same as other cultures. I can easily and quickly adapt to others needs in most situations. I think that being able to do this will help me tremendously in dealing with parents from different cultures. I think it will show them that I have a respect for them and their way of life, and will encourage them to be more respectful when dealing with me.Authors considering attachment in non-western cult...I think that respect is a big issue with almost all cultures and I want to make sure that I am always treating others with respect. I al so would not want parents to feel uncomfortable talking to me about any issue that they may be having.The main reason I see myself in the adaptation stage is that I have grown up working with and playing with and dealing on a daily basis with people from different cultures. I wouldn't say that I could integrate with any other culture completely, but I am able to adapt to their ways of doing things at least for small periods of time when needed. I was never really in the denial stage because I have always know that there are cultural differences in people, and I am able to recognize them fairly quickly. Also I have never really looked at the difference...

Tuesday, March 3, 2020

How Teachers Should Rethink the Summer Work Packet

How Teachers Should Rethink the Summer Work Packet Simply stated: Summer vacation has a negative impact on academic performance. In the book  Influences And Effect Sizes Related To Student Achievement  (updated 2016) by John Hattie and Greg Yates,  39 studies  were used  to rank the effect of summer vacation on student achievement. The findings using this data  are posted on the  Visible Learning  website. They noted that  summer vacation has one of the greatest negative effects (  -.02 effect) on student learning. To combat this negative impact, many teachers in middle and high schools are encouraged to create discipline-specific summer assignment packets. These packets are an attempt to equalize academic practice for all students during summer  vacation. The summer assignment packets that teachers distribute at the end of a school year are designed for students to practice  a few hours every week  throughout the summer. What happens in reality, however, is that completing the summer packet often turns into a  contentious activity. Students may wait until the last possible moment to do schoolwork or lose the packet entirely. Additionally, depending on the grade level, subject, or teacher, summer work packets vary in quality, length, and intensity. Examples of high school summer assignments on the Internet vary from two pages of geometry that can be completed online to  22 pages of geometry problems that must be downloaded to complete. Multiple Advanced Placement courses, such as AP English Literature, show the disparity in summer assignments with some schools offering a choice (Read three novels from this list) to a required five novels matched with pages and pages of worksheets. There is no standardized summer assignment packet for middle and high schools. Who Complains About Summer Assignment Packets? Complaints against the assigned summer work packets come from each of the stakeholders: parents, teachers, and students. Their complaints are understandable. Parents may  argue for freedom from summer assignment packets suggesting that â€Å"My child needs a break,† or  Ã¢â‚¬Å"Why must we do this to students every summer?† or This is more work for me than for my child! Teachers are not happy to begin the school year with a pile of summer assignment papers to grade. Despite their best intentions in creating the packets, they do not want to start the year collecting or chasing students for summer assignment work.   Harris Cooper,  chairman of the department of psychology and neuroscience at Duke University, addressed these  concerns in his brief essay Forgotten on Vacation. His response was featured in  an editorial debate in the New York Times titled  The Crush of Summer Homework  in which several prominent educators were asked their opinions on summer assignments. Cooper was one who chose to respond as to how parents can meet the demands of the summer assignment packet: Parents, if the assignments are clear and reasonable, support the teachers. When your child says I’m bored (what parent hasn’t heard this on a rainy summer day?) suggest they work on an assignment. He also responded to the concerns of teachers: My advice? Teachers, you need to be careful about what and how much summer homework you assign. Summer homework shouldn’t be expected to overcome a student’s learning deficits; that’s what summer school is for. However, in another response, What Low Achievers Need,  Tyrone Howard, associate professor at the UCLA Graduate School of Education and Information Studies, suggested that summer assignment packets do not work. He offered an alternative to the summer assignment packet:   A better approach than homework is to have more intensive, small learning community-type summer school programs that last four to six weeks. Many educators who contributed to the NY Times debate   The Crush of Summer Homework  viewed summer assignments as  a measure of accountability or student responsibility rather than an academic practice. They argued that many of the students who do not complete homework assignments as academic practice during the school year are unlikely to complete summer assignments. Missing or incomplete work is reflected in student grades, and missing or incomplete summer assignments can damage a students grade point average (GPA). For example, some of the summer work assignments posted for high school students on the Internet include warnings, such as: Certain mathematical practice packets may take more than one day to complete. Dont wait until the last minute!The teacher will personally consult with the student and/or parent if  the student does not hand in the summer work packet on the first day of class.This work will be 3% of your first quarter grade. 10 points will be deducted for each day it is late. Seeing the impact on a students GPA for incomplete or missing summer work, many educators argue, If teachers cannot get students to turn in homework during the school year, especially when they see them every day, what is the chance that these summer work assignments will be completed? Student Complaints But  students are the  most vocal group arguing against the summer assignment packet.    The question  Should students be given summer homework?  was featured on  Ã‚  Debate.org.   18% Students say Yes to summer assignments82% Students say No  to summer assignments Comments from the debate arguing against summer assignments included: Summer homework takes around 3 days and it feels like the whole summer  (7th grade student).Mostly summer homework is just a review so you dont really learn anything. Im going into 8th grade and Im not learning anything its all a review for me.If a student really wants to learn, they will do extra work, without it being assigned.The homework should just be suggestions, to stop students from stressing out over work that probably wont even be checked. In contrast, there were some students who saw value in summer assignments, but most of these comments reflected the attitudes of students who already expected additional work from their advanced level classes. I, for example, am going to be enrolling in an Advanced Literature course next year and have been assigned two books to read this summer, an essay to write... this pushes me to find out more information about the subject matter that will be in the course. While students who take the advanced level (Advanced Placement, honors,  International Baccalaureate, or college credit courses) like the one above fully expect to engage in an academic practice, there are other students who do not see the importance keeping their academic skills sharp.  While a summer packet is designed to help all students, regardless of ability, the  student who may not complete the work may be the very student who most needs the practice. No Buy-in from Students In an interview posted on Great Schools,  Denise Pope, senior lecturer at the Stanford University School of Education and co-founder of  Challenge Success, a research, and student-intervention project, agrees that the months off for summer vacation is too long a time for students to not do anything, but she expressed concern stating  I’m not sure this idea of giving workbooks and pages and pages of handouts works.†Ã‚  Her reason for why summer assignments may not work?  No student buy-in: â€Å"In order for any learning to be retained, there has to be engagement on the part of the students.† She explained that students must be intrinsically motivated to complete the systematic practice that is designed for the summer assignments. Without student motivation, an adult must monitor the work, which according to Pope, puts a burden more on the parents.† What Does Work? Reading! One of the best research-based recommendations for summer assignments is to assign reading. Rather than spending the time to create and then grade a summer assignment packet that may or may not be done at all, educators should be encouraged to assign reading. This reading can be discipline specific, but by far, the best way to have students maintain academic skills during the summer-at every grade level- is to encourage their motivation to read. Offering students choice  in reading can improve their motivation and participation. In a meta-analysis titled  Reading Takes You Places: A Study of a Web-based Summer Reading Program,  Ya-Ling Lu, and Carol Gordon recorded ways that student choice in reading increased engagement which led to improved academic achievement. In the study the traditionally required reading lists of classics were replaced with   recommendations based on several of the following  research-based guidelines: 1. People who say they read more read better (Krashen 2004), therefore the primary purpose of the [summer] program is to encourage students to read more.2. In order to encourage students to read more, the primary purpose of summer reading is reading for fun rather than for academic purposes.3. Student choice is an important element in reading engagement (Schraw et al. 1998) including the choice to pursue personal reading interests.4. Materials and materials access can be Web-based (Note:  92% of teens report going online daily - including 24% who say they go online â€Å"almost constantly,† Pew  Research Center) The results showed an increase in student motivation and engagement, leading to improved academic performance. Summer Packets vs. Reading Despite the research  that proves motivation and systemic practice must be in place for summer assignment packets to help the student,  many teachers, particularly at the middle and high school levels, will still assign summer work packets. Their time and effort, however, may be better spent assigning reading in their content area, and where possible, offering student choice in reading. While summer vacation allows students to have time to play and to relax, why  not encourage students to practice over the summer the kind of academic practice that reinforces a life-long critical skill, the skill of reading? Additional Research on Summer Reading: Allington, Richard.  Summer Reading: Closing the Rich/Poor Reading Achievement Gap.  NY:  Teachers College Press, 2012. Fairchild, Ron. Summer: A Season When Learning is Essential. Afterschool Alliance. Center for Summer Learning. 2008. Web. afterschoolalliance.org/issue_briefs/issue_summer_33.pdf Kim, Jimmy. â€Å"Summer Reading and the Ethnic Achievement Gap.† Journal of Education for Students Placed at Risk (JESPAR). 2004. Web. ala.org/research/librariesmatter/node/161 Krashen, Stephen. Free Reading. Pasco School District. School Library Journal. 2006. Web. psd1.org/cms/lib4/WA01001055/centricity/domain/34/admin/free reading (2).pdf National Summer Learning Association. n.d.  summerlearning.org/about-nsla/ Report of the National Reading Panel: Findings and Determinations of the National Reading Panel by Topic Areas.† National Institute of Health. 2006. Web. https://www.nichd.nih.gov/publications/pubs/nrp/Pages/findings.aspx

Saturday, February 15, 2020

Interpretation of financial statement Essay Example | Topics and Well Written Essays - 1000 words

Interpretation of financial statement - Essay Example 60% (2010) = (17,250,000) / 53,580,000 = 32.19% Debt to Equity Ratio Debt to Equity Ratio = Total Debt / Total Equity (2011) = (33,760,000) / 37,160,000 = 90.85% (2010) = (17,250,000) / 36,330,000 = 47.48% Interest Cover (TIE) Interest Cover = (Earnings before Interest and Taxes + Interest Expense) / Interest Expense (2011) = (12,920,000+ 2,000,000) / 2,000,000 = 7.46x (2010) = (16,905,000 + 1,700,000) / 1,700,000 = 10.94x Profitability Ratios Gross Profit Margin Gross Profit Margin = Gross Profit / Sales (2011) = 25,800,000 / 61,000,000 = 42.30% (2010) = 33,980,000 / 73,200,000 = 46.42% Operating Profit Margin Operating Profit Margin = Operating Profit / Sales (2011) = 14,920,000 / 61,000,000 = 24.46% (2010) = 18,605,000 / 73,200,000 = 25.42% Net Profit Margin Net Profit Margin = Net Profit / Sales (2011) = 7,320,000 / 61,000,000 = 12.00% (2010) = 9,578,000 / 73,200,000 = 13.08% Return on Assets Return on Assets = Net Profit / Total Assets (2011) = 7,320,000 / 70,920,000 = 10.32% (2 010) = 9,578,000 / 53,580,000 = 17.88% Return on Equity Return on Equity = Net Profit / Total Equity (2011) = 7,320,000 / 37,160,000 = 19.70% (2010) = 9,578,000 / 36,330,000 = 26.36% Return on Capital Employed (ROCE) Return on Capital Employed = (Earnings before Interest and Taxes/Capital Employed)* (2011) = 14,920,000/55,160,000 = 27.05% (2010) = 18,605,000/47,330,000 = 39.31% * Capital Employed = Total Assets – Current Liabilities MARKET RATIOS Earnings per Share Earnings per Share = Net Profit / (Average no. of Outstanding shares) (2011) = 7,320,000 / (20,000,000) = ?0.37 (2010) = 9,578,000 / (18,000,000) =?0.53 Book Value per Share Book Value per Share = Common Equity / (Average no. of Outstanding shares) (2011) = 37,160,000 / (20,000,000) = ?1.86 (2010) = 36,330,000/ (18,000,000) =... BLS Ltd., manufacturer and supplier of customized furniture and fittings in the UK construction market has expanded its operations in newer markets in recent times. The company’s performance improved significantly up till 2010 as the new management which took over in 1996 made strong decisions and adopted an approach based on quality and perseverance. However, analysis of the company’s financial ratios suggests that its financial performance has deteriorated considerably during the last year.Liquidity Ratios The current ratio of the company is just acceptable at 1.27. However this ratio has declined from 2.54 to 1.27. This is a worrying sign for the company as it implies that the company is just about covering its current assets with its current liabilities. In other words, the company is finding it much more difficult to meet its short term obligations now than a year ago (Besley et al. 2008). As a result, the working capital of the company has also decreased by a sign ificant margin. Consequently, BLS Ltd.’s liquidity position has also worsened. The decrease in Quick/Acid Test Ratio from 1.36 to 0.68 is also quite alarming. This ratio is obtained by removing inventories from the equation which are considered to be the least liquid of all assets. This ratio implies that the company is covering just around 68% of its liabilities. The chief reason for these changes is the increase in current liabilities by more than 100% as the company has expanded its activities.

Sunday, February 2, 2020

Factors That Influence Consumers Purchasing Decision Essay

Factors That Influence Consumers Purchasing Decision - Essay Example The researcher states that a mind map has been developed in order to explain the various factors that are observed to largely influence the buying procedure of iPhone 5S. A group debate has also been conducted in order to analyze the aforesaid subject matter, i.e. the patterns of consumer behavior in the iPhone 5S market context. In relation to the findings obtained, it can be apparently observed that psychological, personal, social and situational factors impose strong influences on consumers’ purchasing decisions. Furthermore, the group debate revealed various internal along with external factors that play a distinctive role to determine the selection and purchase procedures of products and/or services as followed by consumers in the modern-day markets. Consumer behavior is described as the study of the activities that commonly involve searching, evaluating and purchasing of specific products or services followed by the customers in satisfying their respective requirements. This concept mainly concentrates on how people make decisions concerning the utilization of money, time and effort on consuming products and/or services. In other words, it can be affirmed that consumer buying behavior can be described as the activities with respect to acquisition, utilization, and disposition of products, services, thoughts, and experiences. In the field of marketing management, consumer behavior explains the reasons and logic that trigger purchasing decision and consumption pattern of the buyers. It elucidates the procedure by which, consumers make purchasing decisions. This definition clearly exhibits the idea that consumer behavior is a decision-making procedure, which begins in the mind of the customers and leads towards a set if short-listed substitute products or services that can be purchased or availed to suffice their requirements. Subsequently, understanding consumer behavior is important because it assists organizations to develop strategies and ensure s uccessful attainment of their marketing goals.

Saturday, January 25, 2020

Facilitating Change in Health and Social Care Management

Facilitating Change in Health and Social Care Management Summary There needs to be a summary of the major points, conclusions, and recommendations. It needs to be short as it is a general overview of the report. Some people will read the summary and only skim the report, so make sure you include all the relevant information. It would be best to write this last so you will include everything, even the points that might be added at the last minute. Normally it start with past tense Introduction According to Kotter (1999), change management is a set of principles, techniques, and prescriptions embed to the human aspects of executing major change initiatives in organisational settings. It is strategic tool deploy by management to re-direct the use of resources, business process, budget allocations, or other modes of operation that radically reshape a company. The focus of this report is on Beacon Edge Care Home(BECH), a care home that provides support and care for 33 people with Dementia. An inspection was conducted on 21th and 22th of November 2016, and on the 13 of December 2016 unannounced by the Care Quality Commission (CQC) and the outcome of the inspection indicated that Beacon Edge Care Home has not made any improvement based on the recommendations of the first inspection conducted by CQC and the home does not have a registered manager on duty at the time of the inspection.   Regulatory body later found out that BECH does not even have a registered manager as stipula ted under Health and Social Care Act 2008 (Edwards, 2013). The Act indicated that it is mandatory that registered providers of care have a registered persons. A Registered person have legal responsibility for meeting the requirements under Health and Social Care Act 2008 and has the necessary qualifications, competence, skills and experience to supervise the management of the regulated activity (CQC, 2017). The researcher of this report will be the new manager of BECH and will be responsible for implementing change within the organisation.   The manager will need to identify and make required changes before the next inspection by CQC According to Kotter (1999), to implement change in an organisation, the firm have to understand their environment, their strengths and weaknesses and identify areas of improvement that could lead to change management. Hence, to gain a clearer of pictures of the problems facing Beacon Edge Care Home, the researcher will need to conduct a PEST analysis to identify the strength and weakness and areas of improveme nt of BECH. The key factors that can bring change in Beacon Edge Care Home management is be by conducting identifying the strength, weaknesses, areas of improvement as well as turning weaknesses to opportunities. The PEST Analysis and SWOT Analysis will be deployed as factors that can drive change in Beacon Edge Care Home. A PEST analysis is an analysis of the external macro-environment that affects all firms. It helps organisation to determine how political, economic, social and technology can impact the performance and activities of an organisation in the long-term (Daft, 2011). Political Factors Beacon Edge Care Home would assess the political factors affecting its organisation for failing to comply with regulatory bodies like Care Quality Commission. In the report, CQC indicated that their recommendations from the first visit was not implemented and BECH violated   health and safety Act 1974 by not having adequate   care plans and risk assessments to meet the individual needs of people who used their service   and medicines given to service users were poorly managed, hence people are placed at risk of not receiving their medicines as prescribed (Devorshak, 2012).BECH breaches different regulations in the BECH for not   providing adequate care for their service users. Person centred approach was not notable during the CQC visit, there was lack of good governance and staffing, servicers were given the wrong medicine and local health and social care professionals were concerned about the inconsistent of management team in the home. For the new manager to facilitate cha nge in the organisation, all regulatory bodies and environmental issues will need to evaluated and change to meet the needs of the service users. Economic Factors Beacon Edge Care Home should review their employment policies and ensure that it is in compliance with health and Social care requirement of employing candidate that have the right skill set needed in the establishment (Devorshak, 2012). The report indicated that service rendered by BECH to their clients was not adequate and staff lack the understanding and the requirements of the Mental Capacity Act 2005. Training and development strategy will need to be deployed by the new manager to continually improve the skill of the workforce. Social Factors The manager of Beacon Edge Care Home would need to conduct critical evaluation how the organisation meet the needs of the patients Beacon Edge Care Home. The gap in service delivery will enable the manager to understand the areas that need immediate change (Devorshak, 2012). The CQC report indicated that employees of the organisation have no idea how to meet the cultural and social needs of the patients Technology The new manager of Beacon Edge Care Home should investigate how technology can enhance the delivery of quality service to their patients. This can be conducted by looking at current quality cycle of the service provided and factor areas that will be easier to implement with the introduction of technology. SWOT Analysis SWOT Analysis (Strengths, Weaknesses, Opportunities and Threats) is a strategic tool used by organisations to understand their strengths and weaknesses, and to identify their opportunities and threats (Rego and Nunes, 2010).Strengths and weaknesses analysis the internal structure of the organisation, while opportunities and threats generally relate to external factor that the business do have control of (Rego and Nunes, 2010).The researcher will focus on the internal structure of the Beacon Edge Care Home by looking at the strengths and weaknesses. Strengths The strength of Beacon Edge Care Home is the staff. People that were spoken during the inspection indicated that the staff were very caring, pleasant and helpful. Patients were comfortable with the staff as well as they find them very friendly helpful. Further, visitor to the home also indicated that the staff were excellent. The management is blessed with good staff. However, the management lack leadership and do not follow the regulatory bodies criteria especially noncompliance with Health and Social Care Act 2008. Weaknesses Beacon Edge Care Home lack leadership. CQC report on the inspection of BECH indicated that the care and service provided by the organisation is not fit for purpose. Confidential information is not kept secured and did not meet the requirements of the Data Protection Act 1998. There are catalogues of regulation breaches and there is was no registered person on the premises during the time of the inspection that can help the organisation to meet the requirement of different regulatory bodies. The two major weaknesses   are lack of leadership and skilled workers that understand the requirement of Data protection, Act, Health and Safety Act 1974 and the Mental Capacity Act 2005. The new managers will need to evaluate the weaknesses of the organisations such noncompliance with regulations bodies, lack of leadership and lack of training for the employees in order to implement changes in the organisation. The home has good and dedicated staff, Beacon Edge Care Home can tap into by providing leadership, firstly getting a registered person on board and providing training and development for existing staff as well as employing staff with key skills to fill the gaps identified. Opportunities The new managers can help to turn things around in the organisation. There is opportunity to recruit and train existing staff on different requirements associated with health and social care The report by CQC on BECH highlighted most of issues the company need to resolve and this   presents the opportunity for BECH to implement these changes in order to improve their rating   health and social care rating,  Ã‚   customers satisfaction, staff satisfaction and other stakeholders 1.2 The challenges that key factors of change bring to health and social care services Business organisations are faced with different challenges. The health and social care organisations are not immune from these challenges as well. The critical evaluation of the Care Quality Commission report on Beacon Edge Care Home clearly shows that the organisation is faced with various challenges such as: Lack of management support Financial resources Equipment Lack of leadership, Training and development for employee Shortage of staff with key skills, Maintaining quality Effective use of resources Noncompliance with different regulatory bodies. Lack of communication and coordination To implement change, Beacon Edge Care Home must address these issues. 1.2.1 Lack of leadership The CQS report on the home shows that the organisation lack leadership. Daft (2011) describe leadership as individual that have the ability to inspire, mobilise and encourage people to achieve the goals of an organisation. A leader has to be organised, have the ability to delegate task and ensure that all the arms of the business is consistent with all the goals of the organisation. Beacon Edge Care Home lack leadership that is organised, coherent and the ability to inspire staff to meet the objectives of the home (Edwards, 2013). For instance, there was no registered manager on duty during the inspection and no senior management oversight to help ensure effective quality monitoring and improvements were carried out.   The management of Beacon Edge Care Home would need to employ a registered manager according to the Health and Social Care Act 2008. Registered persons have legal responsibility for meeting the requirements in the Health and Social Care Act 2008 and associated Regulat ions about how the service is run. 1.2.2 Lack of management support Change is hard to implement without the support of the management. Shore (2012) suggested that management should be in the forefront of supporting desirable change because such change will increase the profitability of the company. It is obvious from the case study that the management of BECH is in shambles and the management do not have an idea of what is needed to improve the delivery of their services to their patients. This is one   of the main challenges facing the organisation. The managers must employ a democratic leadership that will enable all employees to cultivate a culture of quality assurance in order for BECH to meet the regulatory bodies requirement and to effectively meet the needs of their service user. 1.2.3 Financial Resources The process of implementing change in an organisation can be affected with lack of financial resources.   Financial resources maybe recruiting top notch manager, training employee to meet the expectation of customers or fund to acquire new equipment.   In the case of BECH, the business is faced with different problems and financial constraints maybe one of them. It could be the reason why the company did not employ competent and skilled workforce for effective management of their operations and services. 1.2.4 Lack of communication and coordination Communication at Beacon Edge Care Home was ineffective, wrong drugs are given to patients, staff are not clear on their roles and management Care plans were not focused on upon individual preferences, choices, needs and abilities, in addition, patients received inconsistent care because staff focused on tasks rather than supporting people with their individual needs and preferences. The roles of individual staff need to be defined and the quality of their work would need to be monitor by their supervisor. Supervisor should schedule meetings with staff on a regular basis to communicate what need to be achieved and the approaches staff need to deployed to achieve those goals. 2.1 In relation to the CQC report on Beacon Edge Care Home, the strategy and criteria for measuring recent changes in health and social care have to be effective and efficient.   Hence, it is essential to set up a system that will allow the organisation to know the changes made will work, how to know changes that resulted in improvement and which changes is most vital and have resulted in the most significant improvement. Thus, by collecting data before, during, and after the change have been implemented, Beacon Edge Care Home can measure, evaluate, and compare their home progress with respect to the goals set out. The process of measuring changes should be simple to implement and have immediate impact. Based on these facts, the researcher decided to deploy the use of questionnaires and surveys, interview with service users and employees and discussion with other stakeholders to measure improvement in the services provided by Beacon Edge Care Home. According to Davis (2010), criteria is a standard set by organisation as target that is decided upon.   Setting criteria will enable Beacon Edge Care Home to identify areas that needed improvement and base line for measurement. The Home will need to consider the new and previous recommendations made by CQC which that services provided by the Home have to be effective, responsive, safe, well-led and caring in order to meet the expectations of their service users. A strategy is the direction and scope of an organisation over the long-term: which achieves advantage for the organisation through its configuration of resources within a challenging environment, to meet the needs of markets and to fulfil stakeholder expectations. The plan for strategic and measurement will need to address the factors identified by the CQO in the report and to meet the criteria of the Health and Safety Act 2008. Questionnaire is a qualitative method that can be used to   measure gather information from service user about effectiveness of the service provided. According to Creswell (2014), questionnaire is a research instrument with a written set of questions given to people to collect facts or opinions about a study. It a relatively cheaper and efficient way of collecting large amounts of information a sample of people. In the case, the questionnaire will be design to rate the effectiveness of the service provided, if the staff are responsive and caring, also if the Home conduct risk assessment on their patients and their environment. This will provide a compressive idea of the changes that have been implemented is effective and improve the level of service to the stakeholders. Questionnaire is an effective instrument because it will provide management fast result and it can be easily quantified. It can be used to measure customer or staff satisfaction. Interview is a qualitative approach of gathering information from participants. Interviewing involves asking questions and getting answers from participants in a study.   Interviewing has a variety of forms including: individual, face-to-face interviews and face-to-face group interviewing.   The asking and answering of questions can be mediated by the telephone or other electronic devices (e.g. computer (Wiley, 2014). Interviews can be structured, semi-structure or unstructured. The use of interview techniques at Beacon Edge Care Home to collate data from patients and other stakeholders will provide an insight into the quality of service rendered by the organisation. This can be a semi structured interview by asking patients about specific question about the quality of service and the organisation is meeting their needs in terms of caring, responsive and effective. These approaches and strategies will enable the management of Beacon Edge Care Home to measure the effectiveness of the changes made to meet the criteria of the CQO. CQC drives improvement in the quality of health and social care services. It regulates against the registration requirements set out in regulations to the 2008 Act. These are the essential standards of quality and safety that providers are legally required to meet. These standards therefore represent the minimum quality bar which all providers of regulated activities must meet and should not dip below. 2.2 Measuring the impact of recent changes on health and social care services against set criteria Creswell (2014) defined data collection as the process of gathering and measuring information on variables of interest, in an established systematic fashion that enables one to answer stated research questions, test hypotheses, and evaluate outcomes. In the case of Beacon Edge Care Home, compliance and adherence report, employee engagement and participation, Issue, compliance and error logs, observation of behaviour change, employee feedbacks and employee readiness assessment results were used to measure the recent changes against the set criteria.   Observation of employee engagement with service users, issue, compliance and error logs as well as the employee feedbacks provided crucial information about the changes made at Beacon Edge Care Home against the recommendations made by the CQO. The changes ade by the manager of BECH has enhanced the communication between care workers and service user, improved the provision of person centred care, the management if medicine which was a major problem before and effective care home engagement to ensure that patients are not exposed to any hazard or risk that may cause them harm. 2.3 The overall impact of recent changes in health and social care The recent changes made by the manager and management has improved the quality of service provided by by Beacon Edge Care Home. The appointment of a registered person that understand the criterias and codes of conduct of health and social care, enabled the organisation to comply with various regulations and legislations. For instance, a competent and qualified person was assigned by the manager to monitor and measure health and safety procedures in the organisation. This include conducting risk assessment, reports of incident, communicating changes in operational model to management etc. The registered person on the other hand ensured that training and development are provided for employees, observation conducted to ensure staff are effective and responsive on delivering their duties and survey on patients to measure their level of satisfaction. In most organisation, changing the ways of doing things can either lead to positive or negative outcome. However, the most essential is to h ave management that is open to change and not afraid to implement new approaches. Hence, Beacon Edge Care Home need to continuously monitor and measure the changes that have just been implemented and also look for areas of improvement to in order to meet the ever-changing needs of their service users (Shore, 2012). 2.4 Propose appropriate service responses to recent changes in health and social care services There many approaches and techniques BECH can deployed to response to recent changes in health and social care services The Care Act 2014 underpin the way people receive care and provide a vehicle to communicate changes health and social care services. Regarding BECH, the management can response to recent changes in health and social care services through the following: Training: The case study highlighted BECH lack skilled employees that understand the regulatory requirement of working in health and social care organisation. This will need to be addressed either by employing skilled workers or providing training for old workforce to gain the competency of needed to be a care worker. Compliance with different regulatory bodies requirements: There were different breaches of regulations during the inspection by CQO. For instance, confidential data were not kept secured (Data Act violation), Health and Safety of service user and staff did not comply with the requirement of Mental Capacity Act 2005. The new registered person or manager has to ensure that the cultivate a culture of quality management and effective communication of different policies, procedure and regulations of health and social care to the workforce Continuous quality improvement of services rendered by the organisation: BECH should continue toi improve the level of their service delivery through the quality management tools like Kaizen quality control or quality cycle of Deming. According to Coy and Adams (2012) quality Management tools help organisation collect and analyse data for employees to easily understand and interpret information. Quality Management models require extensive planning and collecting relevant information about end-users. Customer feedbacks and expectations need to be carefully monitored and evaluated to deliver superior quality products. By embracing this approach, BECH, management will be able to meet and exceed the expectations of their service users. Embrace current best practice to treating people and supporting the specialist needs of people living with dementia:BECH provides care and home for people with dementia. It is essential the company lassie with other service providers, professional sand specialist in the field of providing care for people with dementia in order to provide appropriate and adequate service to their clients. Monitoring and managing medicines administered in the way that meet the requirement of the regulatory body: To meet the requirement of Mental Capacity Act 2005, the manager BECH have to monitor and manage the way drugs are administered to their patients. This was one of the findings in the inspection by CQO, patients were given the wrong drugs which can make their situation worse. 3.1 The key principles of change management In the todays business environment, change is inevitable and understanding the principles of change is equally vital. There different principles of change that Beacon Edge Care Home can deploy to meet the expectations of their service users and the objectives of the organisation. John M Fisher and John Kotter are change management theories that have made significant contribution to the subject. Others are Kurt Lewins change management model, Burke-Lewins causal change model; action research; gap analysis and Kà ¼bler Ross transition cycle. The researcher will focus on John Kotters Change Model that consist of eight stages. 3.1.1Establish a sense of urgency: Beacon Edge Care Home need to implement change immediately to meet the criteria and recommendations of the CQO 3.1.2 Form a powerful guiding coalition: The organisation need to employ a registered manager that will help coordinate the process to meet the recommendations set on the report about the Home. 3.1.3Create a clear vision; The manager and management have to set a clear vision on what they need to achieve and the changes that need to be made for the survival of the business. 3.1.4 Communicate the vision; The objectives will need to be communicated to the employees and other stakeholders. 3.1.5 Empower others to act on the vision: Training and development for employees, recruitment of skilled specialist is crucial to meet the vison set for change. 3.1.6 Plan and create short-term wins: The plan to me measurable in short term and long term to know if the changes implemented is working. 3.1.7 Consolidate improvements and produce still more change: Need to conduct survey, questionnaires and interview to measure improvement and benchmark the process in order to continuously improve the quality of the service delivery. 3.7.1 Institutionalise new approaches: After measurement of the impact of change and improvement, areas with positive outcomes and improve should be institutionalised. 3.2 How changes in health and social care are planned There are different approaches and techniques that can be deployed in health and social care setting to manage and plan change. However, it is essential to identify areas that needs change and improvement. Regarding Beacon Edge Care Home, the areas that need change and effective planning are the management style, Staff development needs, communication channel and reconditioning. In addition, changes in health and social care   have to consider the local authority, CCG, community needs, quality of care and finance available to BECH before planning can commerce. 3.2.1 Management style is the principles that underline the methods, abilities and techniques managers use in handling situations and expressing leadership within an organisation (Moss and Moss, 2012). The report on the services rendered by Beacon Edge Care Home by CQO was classified as been ineffective, unresponsive, unsafe and not well managed. The management style deploy by the organisation is not meet the needs of the service users and the goals of the Home.   The report indicated that employees do not have an understanding of their roles and duties, hence, the management are communicating with staff about what is expected of them. By embracing a paternalistic style of working the manager decide what is best for the employees as well as the organization. The policies are devised to benefit the employees and the organization. In addition, employee play a part in the decision making and roles and duties of individual staff are communicated to them. By deploying management style, employees would feel attached and loyal to the organisation. 3.2.2 Staff development needs is essential to meet the needs of the service users, in the report, CQO indicated that staff lack the essential training to be a mental nurse. And there were breaches of regulation in relation to person centred care, safe care and treatment, safeguarding service users from abuse and improper treatment, meeting nutritional and hydration needs, good governance and staffing. Lack of staff development through training has led to the health care provider providing inadequate care. There was also lack of effective communication channel between the management and employees which made it difficult for staff to understand their roles and duties in the establishment.   By investing in training and development, staff will be able to acquire the necessarily skills to conduct their duties appropriately and effectively. 3.2.3 Reconditioning refers to an organisation restructuring their goals and objectives to meet the criteria and regulations of sector they operate (Moosavi, 2009). Beacon Edge Care Home clearly deviated from the codes of conduct of health and social care and the criteria of the CQO. Reconditioning will enable the organisation to evaluate the regulations and legislation they have to adhere to meet the criteria of CQO in order to meet the expectations of their service users. 3.3 Monitoring recent changes in health and social care services Effective monitoring of change in the health and social care involves the systematic and analyse of information collected to measure change and meet objectives and help management to make informed decisions (Haluza and Jungwirth, 2016). The monitoring process comprises of internal and external analysis to measure changes. Internal analysis will usually involve supervisors, managers, clinical audit team, team leaders or a registered person. While, external monitoring comprises of CQC, CCGs, Monitor, Audit Commission and Health inspectors. Monitoring is essential in an organisation because it helps to track implementation and outputs systematically, and measure the effectiveness of programmes. It helps determine exactly when a programme is on track and when changes may be needed (Haluza and Jungwirth, 2016). There are various approaches Beacon Edge Care Home can embed to monitor the impact of change in the organisation, some of the techniques are reviewing the service delivery, supervi sion, shadowing, observation, audits, feedbacks, interviews and questionnaires. References Creswell, J. (2014). Research design. 1st ed. Los Angeles: SAGE Publications. Daft, R. (2011). Leadership. 1st ed. [S.l.]: South Western Cengage learning. Devorshak, C. (2012). Plant pest risk analysis. 1st ed. Cambridge, MA: Cabi. Edwards, N. (2013). Implementation of the Health and Social Care Act. BMJ, 346(apr03 1), pp.f2090-f2090. Green, G. (2002). Training and development. 1st ed. Oxford, U.K.: Capstone Pub. Haluza, D. and Jungwirth, D. (2016). ICT and the future of healthcare: Aspects of pervasive health monitoring. Informatics for Health and Social Care, pp.1-11. Kotter, J. (1999). John P. Kotter on what leaders really do. 1st ed. Boston: Harvard Business School Press. Moosavi, S. (2009). Restructure Conflicting Grant Incentives. Science, 326(5952), pp.521-521. Moss, B. and Moss, B. (2012). Communication skills in health and social care. 1st ed. London: SAGE. Rego, G. and Nunes, R. (2010). Hospital Foundation: A SWOT Analysis. iBusiness, 02(03), pp.210-217. Shore, D. (2012). Forces of change. 1st ed. San Francisco: Jossey-Bass. Wiley, N. (2014). Interviewing Herbert Blumer. Symbolic Interaction, 37(2), pp.300-308.

Friday, January 17, 2020

Carbohydrate and Peptide †Based Vaccines: The Way Forward

Abstract Existing treatments and therapies have supported a huge variety of diseases and infections, a significant example being antibiotics. However the increasing presence of multi-resistant bacteria, as well as increased changes observed in the mechanisms responsible for variation in viruses, involving accumulation of mutations within the genes that code for antibody-binding sites (known as antigenic drift), has resulted in these new strains not being inhibited as effectively by those treatments that originally targeted them (Reche, Fernandez-Caldas, Flower, Fridkis-Hareli and Hoshino, 2014). The knock-on effect has been that the bacteria or virus is able to spread more easily, and therapeutic treatments (used after a person contracts a disease), become less effective, unable to work by boosting the host’s own immune system. As a result, it has been recognised that the vaccine offers the advantage of preventing the anticipation of disease occurrence, using advance action to countera ct infection and chronic illness. Prophylactic, and to a lesser extent therapeutic, vaccines are the most cost-effective and efficient alternative to other treatments and prevention of infectious and chronic diseases. They work by causing changes to the T- and B-cells of the adaptive immune system to eliminate or prevent pathogen growth (Plotkin, Orenstein, and Offit, 2013). Going back to the introduction of vaccines more than 200 years ago, these were initially composed of killed pathogens, which although successful, also caused unacceptably high levels of adverse reactions. During the years of research that have since followed, as with the changes observed with antibiotics and other treatments becoming less effective, the need for safer and more effective vaccines has also been acknowledged. In addition, an improved understanding of antigen presentation and subsequent recognition has supported the development of newer vaccine types (Flower, 2013). Equally, whilst many diseases and infections are controlled by vaccines, for some, no vaccines have been developed, including Streptococcus pyogenes, human immunodeficiency virus (HIV) and hepatitis C virus (HCV) (Wang and Walfield, 2005; Barrett and Stanberry, 2009). Efforts to develop new vaccines are discussed in more details, with a focus on peptide-based and carbohydrate-based vaccines. Challenges are also discussed, leading to a summary of the potential direction of vaccination and research, which describes a promising future. Peptide-based vaccines An example of a newer category of vaccine is peptide-based vaccines. Peptides are short sequences of proteins, and diseases/infections use these proteins as part of their attack on the immune system. In many cases, the immune system has the ability to recognise the proteins associated with an attack by disease or infectious causing pathogens and can respond effectively. However as observed with many cancers, HIV, HCV and other conditions, an effective immune response is not triggered, hence the need for newer vaccine developments including those based on peptides, which encompass single proteins or synthetic peptides encompassing many antigenic determinants (B- and T-cell epitopes) (Flower, 2013). Peptide vaccines are a type of subunit vaccine, which presents an antigen to the immune system, using the peptide of the original pathogen, supporting immunity. Such peptide-based vaccines avoid the adverse effects described with traditional whole-organism vaccines (Moisa and Kolesanova, 20 12) with additional benefits also noted (Ben-Yedidia and Arnon, 1997), including: The absence of infectious material An immune response that is specific, focusing only on the targeted epitope, with the induction of site-specific antibodies No risk of an immune attack or cross-reactivity with the host tissues Flexibility, with an ability to modify products accordingly Improved effectiveness in relation to manufacturing on a large scale, and long-term storage where necessary e.g. a pandemic. However, a number of difficulties have been encountered during the development of such vaccines (Simerska, Moyle and Toth, 2011; Dudek, Perlmutter, Aguilar, Croft and Purcell, 2010) including: A short biological activity of peptides due to degradation by enzymes The trigger of a weak immune response when used alone i.e. single peptides Finding optimal delivery systems. As a result, and to overcome the difficulties mentioned above, synthetic peptide vaccines have been developed, on the basis that a greater more accurately targeted immune response will be achieved. Peptide antigens are not immunogenic by themselves, so this has led to investigations into co-administration of subunit peptide antigens with adjuvants (immunostimulants) to increase the peptide-induced responses to corresponding antigens. Appropriate delivery systems and often toxic adjuvants have demonstrated effective immunity, however, although many adjuvants are described in the literature, only a few have been approved for use with vaccines for delivery in humans due to their toxicity and include water/oil emulsions, liposomes, and bacterial lipophilic compounds to offer a few examples (Heegaard et. al., 2010). Incomplete Freund’s adjuvant (IFA) and Montanide ISA (both oil-based) have been used in clinical trials. Focusing on liposomes as another example, researchers have demo nstrated that use of lipid core peptide (LCP) technology (lipidation of peptides) improves the effectiveness of a self-adjuvanting vaccine delivery system, targeting a specific disease and triggering an effective immune response. This system provides a promising platform for human vaccine development (Zhong, Skwarczynski and Toth, 2009; Moyle and Toth, 2008). In animal models, peptide vaccines have been effective in generating the required immune response, and during recent years, peptide-based vaccines have advanced from animal models and pre-clinical studies, to human clinical trials (Yang et al., 2001). Although currently, all known peptide vaccines under development for humans remain at the stage of clinical trials, these trials should build on the promising evidence resulting from research to date of the potential application of vaccine candidates based on a LCP system, as well as other strategies. Prevention of not only many infectious diseases including hepatitis C virus, mal aria, human immunodeficiency virus and group A streptococci), but also for cancer immunotherapy and improved allergen specific tolerance, remains an exciting, and very real possibility. Carbohydrate-based vaccines The development of vaccines based on carbohydrates not only has quite a history, but is also an area that is fast moving in the current research world. The literature provides evidence as far back as the early 1900s where researchers discovered a connection between type-specific polysaccharides and the induction of antibodies being developed against certain types of pneumococci (Francis and Tillett, 1930). This was confirmed by evidence of pneumococcal capsular polysaccharides being used as vaccines, providing effective and long lasting immunity (Heidelberger, Dilapi, Siegel and Walter, 1950). However despite these early findings, the discovery and success of other treatments such as antibiotics and chemotherapeutics led to this area of research being put on hold. As mentioned earlier however, due to increased resistance to existing treatments such as antibiotics, coupled with the recognition for a need of newer treatments including improved vaccines, renewed interest into preventive vaccines has resulted in novel approaches, which include carbohydrate vaccines. Vaccines are commonly made from weakened pathogens, or, as we now know, other approaches also use immunogenic proteins or polysaccharides. Carbohydrates have been the centre of attention in the research field of vaccination because not only do they exhibit more stability than proteins, but they have roles in both physiology and pathophysiology, including cell interaction and signalling, inflammation, pathogen host adhesion/recognition, to name a few examples (Doshi, Shanbhag, Aggarwal, Shahare and Martis, 2011). During the last ten years or so, they have been used as adjuvants, as carriers for protein antigens to aid immunotherapy, and as targets for vaccines against bacteria. Additionally, as observed with DNA and proteins, carbohydrates are now recognised as biopolymers also, playing a role in many molecular and biological activities (Doshi et. al., 2011). These discoveries, partnered by an improved u nderstanding of the immune system and the identification of specific and relevant carbohydrate structures, led to the development of glycoconjugates, which in turn led to carbohydrate vaccine development (Holemann and Seeberger, 2004). Glycoconjugates are present in the surfaces of cells, as well as in the surrounding extracellular matrices and connective tissue. Therefore both the identified structure and presence of glyconjugates, plus the role they play, means they are a suitable basis for the development of new vaccines. Induction of protective antibodies is key to an effective immune response as a result of a vaccine, and as with peptide vaccines, challenges have been evident in the research to develop effective carbohydrate vaccines, including the following: Glycans struggle to effectively induce protective antibodies Carbohydrates have a low immunogenic impact by themselves (as observed with peptides). There are two main carbohydrate vaccine types: 1. Natural carbohydrate vac cines: these include small amounts of impurities 2. Synthetic carbohydrate vaccines: these are produced with no contaminants, and are cost-effective due large-scale production. Synthetic carbohydrate antigens used to develop vaccines have triggered immune responses in clinical studies and are favourable given the risk of adverse effects with natural vaccines. Four crucial aspects need to be considered for the design of carbohydrate-based vaccines (Astronomo and Burton, 2010): The antigen source: glycan antigens are diverse, ranging from large polysaccharide capsules, to small monosaccharides, to oligosaccharides, all of which have been shown to be adequate for preparation of vaccines. The carrier: this is most often proteins, although other materials have been investigated, with the aim of ensuring that the link between the antigen and the carrier is specific. The method of conjugation (or ligation): protein conjugates, lipid conjugates and polyvalent scaffold conjugates have been d eveloped. The success of a conjugate vaccine depends partly on the method of conjugation employed. This should be simple and efficient, as well as causing minimal distortion to the individual components involved, with many differing techniques used (Zou & Jennings, 2009; Ada and Isaacs, 2003). The choice of adjuvant: required to improve immunogenicity of the carbohydrate antigens being targeted, with a limited choice approved for use in humans. Examples of diseases targeted by carbohydrate-based vaccines The discussion will now move on to the use of carbohydrate-based vaccines in three disease areas: Group A Streptococcus (GAS), HIV/AIDS and Haemophilus influenza type b. GAS The need for a safe, effective, affordable and practical vaccine against GAS (also known as Streptococcus pyogenes), has been recognised for many years, as has the research into a vaccine against this disease, given the global burden on health that this disease causes in particular in less developed countries. More than 500,000 deaths result from the GAS each year, with the bacteria causing a range of both less complicated and life-threatening illnesses (Carapetis, Steer, Mulholland and Weber, 2005). The diversity of GAS strains is the major challenge for the development of an anti-GAS vaccine, with more than 100 different strains identified, of which the genetic sequence for several different strains have been determined (Johnson and Pinto, 2002). Rese arch has identified that GAS bacteria contain a surface polysaccharide made up of long, repetitive polysaccharide chains. The conserved and constant arrangement of these chains suggests conjugate vaccines to be an attractive and achievable option, with animal models supporting this theory (Cunningham, 2000). Synthetic carbohydrate vaccines, although only studied in a limited set of GAS infections, have demonstrated a protective immune response (Robbins et al., 2009). In addition, some areas of research have focused on the molecular analysis of a surface protein labelled the M protein, which is encoded by the emm gene. This particular gene has been found to be the major cause of GAS related clinical manifestations (Smeesters, McMillan and Sriprakash, 2010). These findings have allowed a greater understanding of the functioning of specific proteins responsible for the virulence of the disease, which in turn, supports the development of potential GAS vaccines. Vaccine prevention of GAS and the resulting symptoms and complications has been a goal of researchers for many years. A number of vaccines have been in research development to offer protection against GAS, with the research vaccine strategies focusing on either M protein, or non-M protein antigens (Smeesters, 2014). However only those vaccines that use the M protein as the antigen have progressed to clinical trials (McNeil et. al., 2005), and have included conserved antigens coverage across the many strains of GAS, a type-specific vaccine based on the N-terminal portion of the M protein, and a recombinant vaccine that reached phase II clinical trials (Pandey, Wykes, Hartas, Good and Batzloff, 2013; Bauer, 2012). However no vaccine has currently reached licensing and so the diseases caused remain uncontrolled in many areas, with reviews covering the research suggesting that even those vaccines developed with the aim of providing large coverage of GAS strains, these vaccine might achieve acceptable coverage i n developed countries, but in less developed countries where the disease burden is much greater, the positive impact of the vaccines would be much lower due to a greater strain diversity (Smeesters, McMillan, Sriprakash, and Georgousakis, 2009; Steer, Law, Matatolu, Beall and Carapetis, 2009; McMillan and Sanderson, 2013). Equally, antibiotic treatment is either impractical with regards to implementation (specifically in less developed countries) or ineffective. One research group targeted the bacteria by synthesising a new self-adjuvanting vaccine candidate, incorporating a carbohydrate carrier and an amino acid-based adjuvant, resulting in successful synthesis and characterisation of the vaccine candidate. This may contribute to the identification of a safe and effective vaccine against GAS in the future (Simerska et. al., 2008; Simerska, Lu and Toth, 2009). HIV/AIDS One of the main challenges researchers have faced within the field of vaccine development against HIV/AIDS, is that the virus surface is covered with layers of glycans, which conceal underlying viral antigens that are potential good targets in the production of vaccines (Scanlan, Offer, Zitzmann, and Dwek, 2007). They are produced by the host cell, which makes the virus appear as â€Å"self† resulting in no attack being triggered by the host immune system. The layers of carbohydrate also contain mannose residues, making these another potential target for a vaccine aimed at preventing HIV infection, whereby lectins preferentially bind to ? 1-2 linked mannose residues. Such lectins are being investigated as possible therapeutic tools (Tsai et al., 2004) although the fact that lectins are often toxic needs to be researched further to avoid the host immune system damaging host cells. Indeed, other drugs that are known to inhibit synthesis of carbohydrates only have this effect at often toxic concentrations to cause antiviral activity. Another strategy based on the same principle of developing a carbohydrate vaccine, is the identification of antibodies that again recognise and bind to glycans. (Scanlan et al., 2002, Scanlan et al., 2007). The antibody appears to recognize these glycans because although they belong to the host, they are arranged in a â€Å"non-self† manner (Scanlan et al., 2002; Scanlan et al., 2007), making the production of effective ant-HIV vaccines a real possibility, in addition to vaccines for other diseases such as cancer (Galonic and Gin, 2007). Studies have also been described using immune enhancing adjuvants, carrier peptides such as keyhole limpet hemocyanin and altered glycan structure constructs that support immune recognition in the development of vaccines against cancer (Galonic and Gin, 2007). These same strategies are being used in development of possible HIV vaccines, where antibodies target self-carbohydrates arranged slightly differently on cancer cells and HIV-infected cells, in comparison to healthy cells. (Galonic and Gin, 20 07). These approaches have not as yet led to clinically effective vaccines, but it is clear that antibodies that strongly bind to carbohydrate antigens on, for example, prostate cancer cells, have been generated (Slovin et al., 2003) and this appears to be a highly promising approach. Further exploration is required based on the carbohydrate coat of the virus, which may lead to improved prevention treatment of HIV. Haemophilus influenza type b The first synthetic vaccine for human application was developed in 2003 for protection against Haemophilus influenza type b vaccine, not only providing protection against this bacterium, but also against all the associated diseases it causes ranging from meningitis, septicaemia, pneumonia and arthritis (Doshi, Shanbhag, Aggarwal, Shahare and Martis, 2011). Indeed this bacterium is the leading cause of serious illnesses in children under 5 years worldwide. The majority of strains of Haemophilus influenza are non-encapsulated, and are lacking in any carbohydrate polysaccharide protective structure, as opposed to the GAS bacteria and HIV virus described earlier. This structural information armed researchers with the knowledge that carbohydrate polysaccharide conjugate vaccines would be required to ensure the development of an effective vaccine (Verez-Bencomo et. al., 2004). As a result, carbohydrate-based vaccines have been licensed for protection in humans against haemophilus influenza type b, using oligomerization and a carrier protein (Doshi et. al., 2011).Evidence of progressTo end this section of the discussion, several conjugate polysaccharide carbohydrate vaccines are now well into pre-clinical/clinical development, or have been licensed and are now commercially available. Examples of licensed vaccines include the following (Astronomo and Burton, 2010): Haemophilus influenza type b (Hib) – 4 carbohydrate-based vaccines are licensed via 3 different pharmaceutical companies: ActHIB and Hiberix; Pentacel; PedvaxHIB; and Comvax Neisseria meningitides A, C, Y and W-135 – 2 carbohydrate-based vaccines are licensed via the same pharmaceutical company: Menactra; and Menomune-A/C/Y/W-135 Salmonella typhi – 1 carbohydrate- based vaccine is licensed: TYPHIM Vi Streptococcus pneumonia variants – 2 carbohydrate-based vaccines are licensed via 2 different pharmaceutical companies: Prevnar; and Pneumovax 23. Examples of carbohydrate-based vaccines in development include the following, where the disease is described in addition to the phase of development (Astronomo and Burton, 2010): Breast cancer – with 1 vaccine at the preclinical phase and a second at phase I Prostate cancer – 4 vaccines are in development at the preclinical, phase I and phase II stages HIV-1 – 1 vaccine at the preclinical phase Group A streptococcus – 1 vaccine at the preclinical phase Group B streptococcus – 1 vaccine at phase II. Conclusion It is fact that vaccines have had a major role to play in the success of preventing and treating many diseases, however many challenges remain. Diseases exist for which no effective vaccines have yet been discovered, including HIV/AIDs. In addition, diseases that have been controlled by vaccines in some parts of the world continue to affect the lives of people adversely in other areas where infrastructures for vaccination are poor/non-existent. Continued research is necessary to develop vaccines not only for those diseases with no vaccine available, but also to improve the effectiveness of existing vaccines. In addition to research focusing on novel and promising approaches such as carbohydrate and peptide based vaccines, efforts also need to concentrate on areas such as lower cost, more convenient delivery of vaccines, and longer-term protection. The future direction of research in this field has become focused with the help of new evidence-based information and promising data. The advent of synthetic peptide-based and carbohydrate-based vaccines signified a new era for vaccines, over-taking traditional treatments and vaccines which have become either ineffective or only offer short term protection. As the discussion demonstrates, a number of vaccines are already successfully protecting humans against some pathogens and disease, with the potential for further vaccines to follow. 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